Myambutol (Ethambutol) is an antibacterial used to treat tuberculosis (TB).

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Manufacturer Name : M
Product Category: Antibiotics
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Myambutol (Ethambutol) is an antibacterial used to treat tuberculosis (TB).
Synonyms: Aethambutolum, Dadibutol, Diambutol, Etibi, Themibutal, Tibitol, Tibutol
What is the most important information I should know about myambutol? Take all of the myambutol that has been prescribed for you even if you begin to feel better. Your symptoms may begin to improve before the infection is completely treated. Call your doctor immediately if you experience changes in vision (e.g., blurring, red-green color blindness) or a rash.
What is myambutol? Myambutol is an antibiotic. It prevents growth of the tuberculous bacteria in the body. Myambutol is used to treat tuberculosis (TB). Myambutol may also be used for purposes other than those listed in this medication guide.
What should I discuss with my healthcare provider before taking myambutol? Before taking this medication, tell your doctor if you have ?ever had an allergic reaction to myambutol; ?cataracts, diabetic retinopathy, or optic neuritis; or ?kidney disease. You may not be able to take myambutol, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. It is not known whether myambutol will be harmful to an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is also not known whether myambutol will be harmful to a nursing baby. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.
How should I take myambutol? Take myambutol exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you. Take each dose with a full glass (8 ounces) of water. Myambutol can be taken with or without food. Taking myambutol with food may decrease stomach upset. Take all of the myambutol that has been prescribed for you even if you begin to feel better. Your symptoms may begin to improve before the infection is completely treated. Myambutol is usually combined with one or more other tuberculosis medicines. Store this medication at room temperature away from moisture and heat.
What happens if I miss a dose? Take the missed dose as soon as you remember. If it is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take a double dose of this medication.
What happens if I overdose? Seek emergency medical attention if an overdose is suspected. Symptoms of an myambutol overdose are unknown.
What should I avoid while taking myambutol? There are no restrictions on foods, beverages, or activities during treatment with myambutol unless otherwise directed by your doctor.
What are the possible side effects of myambutol? If you experience any of the following serious side effects, stop taking myambutol and seek emergency medical attention or contact your doctor immediately: ?an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); ?vision changes (e.g., blurring, red-green color blindness); ?a rash; ?numbness or tingling in your fingers, toes, hands, or feet ?confusion, disorientation, or hallucinations; or ?fever. Other, less serious side effects may be more likely to occur. Continue to take myambutol and talk to your doctor if you experience stomach upset, nausea, vomiting, abdominal pain, or decreased appetite; headache; mild dizziness; worsening gout; or joint pain. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
What other drugs will affect myambutol? Do not take antacids that contain aluminum within several hours of taking a dose of myambutol. Aluminum will decrease the amount of myambutol that is absorbed by the body. If you need an antacid, ask your doctor or pharmacist to recommend one that is aluminum free. Drugs other than those listed here may also interact with myambutol. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.
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IndicationsMYAMBUTOL is indicated for the treatment of pulmonary tuberculosis, as shown by a large number of studies by investigators throughout the world. It has also been used successfully in cases of primary tuberculosis and extrapulmonary forms of tuberculosis, including miliary tuberculosis, tuberculous meningitis, tuberculosis of bones and joints, genitourinary tuberculosis, tuberculosis of the skin and tuberculous eye diseases. It should not be used as the sole anti-tuberculosis agent, but should be used in conjunction with at least one other antituberculosis treatment. Selection of the companion substance should be based on clinical experience, considerations of comparative safety and appropriate in vitro susceptibility studies.In patients who have not received previous antituberculosis therapy, i.e. initial treatment, the most frequently used regimens have included three of the following agents - MYAMBUTOL, isoniazid, rifampicin and streptomycin - for the first 2-4 months.For example:MYAMBUTOL plus isoniazid plus rifampicinor MYAMBUTOL plus isoniazid plus streptomycinthen continuing with a two agent regimen such as:MYAMBUTOL plus isoniazidor MYAMBUTOL plus rifampicin.In patients who have received previous antituberculosis therapy, mycobacterial resistance to other substances used in initial therapy is frequent. Consequently, in such retreatment cases MYAMBUTOL should be combined with at least one of the second-line agents not previously administered to the patient and to which bacterial susceptibility has been indicated by appropriate in vitro studies. Antituberculosis agents used with MYAMBUTOL have included cycloserine, ethionamide, pyrazinamide, viomycin and other substances. Isoniazid, aminosalicylic acid and streptomycin have also been used in multiple treatment regimens. Alternating treatment regimens have also been utilised.Dosage and AdministrationMYAMBUTOL should not be used alone, in initial treatment or in retreatment. MYAMBUTOL should be administered on a once every 24 hour basis only. Absorption is not significantly altered by administration with food. In general, therapy should be continued until bacteriological conversion has become permanent and maximal clinical improvement has occurred.Initial TreatmentIn patients who have not received previous antituberculosis therapy, administer MYAMBUTOL 15 mg/kg of body weight, as a single oral dose once every 24 hours. In the more recent studies, isoniazid has been administered concurrently in a single, daily, oral dose.Re-treatmentIn patients who have received previous antituberculosis therapy, administer MYAMBUTOL 25 mg/kg of body weight, as a single oral dose once every 24 hours. Concurrently administer at least one other antituberculosis substance to which the organisms have been demonstrated to be susceptible by an appropriate in vitro test. Suitable substances usually consist of those not previously used in the treatment of the patient. After 60 days of MYAMBUTOL administration, decrease the dose to 15 mg/kg of body weight and administer as a single oral dose once every 24 hours.During the period when a patient is on a daily dose of 25 mg/kg, monthly eye examinations are advised.Intermittent TherapyAn alternative method of administration, in both "initial treatment" and "re-treatment" cases, is to give the abovementioned daily dosage of 15 or 25 mg/kg/day for two months or longer, depending on the type and extent of disease and the bacteriological and roentgenographic response (or until at least one negative sputum is obtained). Thereafter MYAMBUTOL may be given in a dosage of 50 mg/kg twice weekly. When isoniazid is administered concomitantly, the usual dosage is 14 mg/kg twice weekly with 10 mg of pyridoxine for each 100 mg of isoniazid.The usual daily dosage of isoniazid in adults is 300 mg, or 5 mg/kg on the basis of body weight. In children the usual daily dosage is 5 to 20 mg/kg.Weight Dose Table for MYAMBUTOL Tablets Weight Range 25 mg/kg Schedule Daily Dose in mg Under 38 kg 900 38-42 1000 42-45.5 1100 45.5-50 1200 50-54 1300 54-58 1400 58-62 1500 62-67 1600 67-71 1700 71-75 1800 75-79 1900 79-83 2000 83-87 2100 87-91 2200 Weight Dose Table for MYAMBUTOL Tablets Weight Range15 mg/kg Schedule Daily Dose in mg Under 37 kg 500 37-43 600 43-50 700 50-57 800 57-64 900 64-71 1000 71-79 1100 79-84 1200 84-90 1300 90-97 1400 Over 97 1500

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